Martínez-Coria Hilda, Mendoza-Rojas Martha X, Arrieta-Cruz Isabel, López-Valdés Héctor E
Division de Investigación, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Ciudad de México, México.
Laboratorio Experimental de Enfermedades Neurodegenerativas, UNAM-INNyN, Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suárez",Ciudad de México, Mexico.
Front Pharmacol. 2019 Nov 11;10:1334. doi: 10.3389/fphar.2019.01334. eCollection 2019.
Brain aging and neurodegenerative diseases share the hallmarks of slow and progressive loss of neuronal cells. Flavonoids, a subgroup of polyphenols, are broadly present in food and beverage and numerous studies have suggested that it could be useful for preventing or treating neurodegenerative diseases in humans. Dihydromyricetin (DHM) is one of the main flavonoids of some Asian medicinal plants that are used to treat diverse illness. The effects of DHM have been studied in different systems of oxidative damage and neuroinflammation, as well as in animal models of several neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. Here we analyzed the most important effects of DHM, including its antioxidant, anti-inflammatory, and neuroprotective effects, as well as its ability to restore GABA neurotransmission and improve motor and cognitive behavior. We propose new areas of research that might contribute to a better understanding of the mechanism of action of this flavonoid, which could help develop a new therapy for aging and age-related brain diseases.
脑衰老和神经退行性疾病具有神经元细胞缓慢且渐进性丧失的特征。黄酮类化合物是多酚的一个亚类，广泛存在于食品和饮料中，众多研究表明其可能对预防或治疗人类神经退行性疾病有用。二氢杨梅素（DHM）是一些用于治疗多种疾病的亚洲药用植物的主要黄酮类化合物之一。已在不同的氧化损伤和神经炎症系统以及几种神经退行性疾病（如阿尔茨海默病、帕金森病和亨廷顿病）的动物模型中研究了DHM的作用。在此，我们分析了DHM的最重要作用，包括其抗氧化、抗炎和神经保护作用，以及其恢复GABA神经传递和改善运动及认知行为的能力。我们提出了新的研究领域，这可能有助于更好地理解这种黄酮类化合物的作用机制，从而有助于开发针对衰老和与年龄相关的脑部疾病的新疗法。
