Gabrilovich Dmitry, Pisarev Vladimir
H. Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA.
Curr Drug Targets. 2003 Oct;4(7):525-36. doi: 10.2174/1389450033490849.
Immune system plays an important role in control of tumor progression. Effective antitumor immune response depends on close interaction of several elements of immune system. They include antigen-presenting cells, different subsets of T cells, B cells and NK cells. However, tumor cells developed a number of mechanisms to escape recognition and elimination by immune system. In this review we will discuss these mechanisms and address possible approaches to correct them.
免疫系统在控制肿瘤进展中发挥着重要作用。有效的抗肿瘤免疫反应依赖于免疫系统多个要素的密切相互作用。这些要素包括抗原呈递细胞、不同亚群的T细胞、B细胞和自然杀伤细胞。然而，肿瘤细胞形成了多种机制来逃避被免疫系统识别和清除。在本综述中，我们将讨论这些机制，并探讨纠正它们的可能方法。
