Terme Magali, Tanchot Corinne
Inserm U970, Paris Cardiovascular Research Center (PARCC), faculté de médecine Paris-Descartes, université Paris-Descartes, Sorbonne Paris Cité, 56, rue Leblanc, 75015 Paris, France.
Inserm U970, Paris Cardiovascular Research Center (PARCC), faculté de médecine Paris-Descartes, université Paris-Descartes, Sorbonne Paris Cité, 56, rue Leblanc, 75015 Paris, France.
Ann Pathol. 2017 Feb;37(1):11-17. doi: 10.1016/j.annpat.2016.12.004. Epub 2017 Jan 31.
Despite having been much debated, it is now well established that the immune system plays an essential role in the fight against cancer. In this article, we will highlight the implication of the immune system in the control of tumor growth and describe the major components of the immune system involved in the antitumoral immune response. The immune system, while exerting pressure on tumor cells, also will play a pro-tumoral role by sculpting the immunogenicity of tumors cells as they develop. Finally, we will illustrate the numerous mechanisms of immune suppression that take place within the tumoral microenvironment which allow tumor cells to escape control from the immune system. The increasingly precise knowledge of the brakes to an effective antitumor immune response allows the development of immunotherapy strategies more and more innovating and promising of hope.
尽管一直存在诸多争议，但现在已经明确免疫系统在抗癌斗争中起着至关重要的作用。在本文中，我们将强调免疫系统在控制肿瘤生长中的作用，并描述参与抗肿瘤免疫反应的免疫系统主要组成部分。免疫系统在对肿瘤细胞施加压力的同时，也会在肿瘤细胞发展过程中塑造其免疫原性，从而发挥促肿瘤作用。最后，我们将阐述肿瘤微环境中发生的多种免疫抑制机制，这些机制使肿瘤细胞能够逃避免疫系统的控制。对有效抗肿瘤免疫反应的阻碍因素的认识日益精确，这使得免疫治疗策略得以不断创新并带来越来越多的希望。
