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Novel synthetic approach to 6,7-dihydro-5H-imidazo[1,5-a]-pyrazin-8-ones.

作者信息

Gopalsamy Ariamala, Shi Mengxiao

机构信息

Chemical and Screening Sciences, Wyeth Research, Pearl River, New York 10965, USA.

出版信息

Org Lett. 2003 Oct 16;5(21):3907-9. doi: 10.1021/ol035455i.

DOI:10.1021/ol035455i
PMID:14535740
Abstract

[reaction: see text] A novel route to highly substituted chiral 6,7-dihydro-5H-imidazo[1,5-a]pyrazine-8-ones starting from Meldrum's acid is disclosed. The key features of the methodology are the incorporation of amino esters as a chiral pool and facile mild intramolecular cyclization to form the pyrazine ring. Incorporation of various substituents at different stages of the synthesis from various building block sets makes this methodology readily amenable to parallel synthesis.

摘要

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