Cobalt-catalyzed carbocyclization of o-iodobenzaldehydes and o-iodophenylketones with alkynes.
作者信息
Chang Kuo-Jui, Rayabarapu Dinesh Kumar, Cheng Chien-Hong
机构信息
Department of Chemistry, Tsing Hua University, Hsinchu, Taiwan 300, ROC.
出版信息
Org Lett. 2003 Oct 16;5(21):3963-6. doi: 10.1021/ol035514s.
PMID:14535754
Abstract
[reaction: see text] Treatment of various o-iodobenzaldehydes and o-iodophenyl ketones with alkynes in the presence of Co(dppe)I(2) and Zn powder in acetonitrile at 80 degrees C afforded the corresponding indenols in moderate to excellent yields with exceedingly high regioselectivity. For most unsymmetrical alkynes tested, the carbocyclization gave a single regioisomer.
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