Amann K, Wiest G, Zimmer G, Gretz N, Ritz E, Mall G
Department of Pathology, University of Heidelberg, Germany.
Kidney Int. 1992 Nov;42(5):1079-85. doi: 10.1038/ki.1992.390.
Using stereological techniques capillaries, interstitium and myocardial fibers were analyzed in perfusion-fixed hearts of subtotally nephrectomized male Sprague-Dawley rats with uremia of 14 months duration (or their sham-operated controls). Uremic rats had higher systolic blood pressure (140 +/- 20.3 mm Hg vs. 119 +/- 6.61 mm Hg) and left ventricular weight/body weight ratio (3.37 +/- 0.09 mg/kg vs. 2.01 +/- 0.12 mg/kg) than controls, and had slight anemia (Hct 35.0 +/- 3.16% vs. 40.4 +/- 3.3%). Length density (Lv) of capillaries, that is, capillary length per unit myocardial volume, was significantly (P < 0.001) decreased in uremia (2485 +/- 264 mm/mm3 vs. 3329 +/- 194 mm/mm3) versus controls. In parallel, surface density and volume density of the capillary lumina were also reduced (7.95 +/- 1.69 cm3/cm3 vs. 11.4 +/- 1.8 cm3/cm3) in the uremic rats. We conclude that in experimental uremia, cardiac hypertrophy is not accompanied by a commensurate increase in capillaries.
采用体视学技术，对持续14个月尿毒症的雄性Sprague-Dawley大鼠（或假手术对照组）进行肾次全切除术后灌注固定心脏中的毛细血管、间质和心肌纤维进行分析。与对照组相比，尿毒症大鼠的收缩压更高（140±20.3毫米汞柱对119±6.61毫米汞柱），左心室重量/体重比更高（3.37±0.09毫克/千克对2.01±0.12毫克/千克），且有轻度贫血（血细胞比容35.0±3.16%对40.4±3.3%）。尿毒症时，毛细血管的长度密度（Lv），即单位心肌体积内的毛细血管长度，与对照组相比显著降低（P<0.001）（2485±264毫米/立方毫米对3329±194毫米/立方毫米）。同时，尿毒症大鼠毛细血管腔的表面密度和体积密度也降低（7.95±1.69立方厘米/立方厘米对11.4±1.8立方厘米/立方厘米）。我们得出结论，在实验性尿毒症中，心脏肥大并未伴有相应的毛细血管增加。
