Panjehpour M, Overholt B F, DeNovo R C, Sneed R E, Petersen M G
Laser/Hyperthermia Department, Thompson Cancer Survival Center, Knoxville Tennessee 37916.
Lasers Surg Med. 1992;12(6):631-8. doi: 10.1002/lsm.1900120611.
A cylindrical balloon was developed to improve delivery of circumferential light for photodynamic therapy (PDT) of esophageal carcinoma. The balloon consisted of a 36-mm-long clear cylindrical membrane and a central tube to hold a cylindrical diffuser in the center of the lumen. Three isotropic probes were placed on the outside of the balloon to allow measurement of delivered light dose to the esophageal mucosa. The balloon was tested in the normal esophagus of 8 dogs that were injected with 4.0 mg/kg of PHOTOFRINR. Endoscopy was performed 48 hours following the injection, and under endoscopic observation the balloon assembly was passed, fixed in place, and inflated. A 1-cm cylindrical diffuser was passed into the central tube and 150, 300, and 600 Joules/cm of 630 nm laser light was delivered at 25 cm, 15 cm, and 5 cm proximal to the gastroesophageal junction. One control dog was illuminated using the cylindrical diffuser alone at doses of 300 and 600 Joules/cm of diffuser. Complete circumferential tissue response was obtained when the balloon was used. Relatively uniform light intensities were measured around the lumen. In contrast, noncircumferential and unpredictable PDT responses were generated when the cylindrical diffuser was used without the balloon.
研发了一种圆柱形球囊，以改善用于食管癌光动力疗法（PDT）的周向光传递。该球囊由一个36毫米长的透明圆柱形膜和一根中心管组成，中心管用于在管腔中心固定一个圆柱形扩散器。在球囊外部放置了三个各向同性探头，以测量传递至食管黏膜的光剂量。在8只注射了4.0毫克/千克光敏剂的犬的正常食管中对该球囊进行了测试。注射后48小时进行内镜检查，在内镜观察下将球囊组件通过、固定到位并充气。将一个1厘米的圆柱形扩散器插入中心管，并在距胃食管交界处近端25厘米、15厘米和5厘米处分别输送150、300和600焦耳/厘米的630纳米激光。一只对照犬单独使用圆柱形扩散器，以300和600焦耳/厘米扩散器的剂量进行照射。使用球囊时获得了完整的周向组织反应。在管腔周围测得相对均匀的光强度。相比之下，在不使用球囊的情况下使用圆柱形扩散器时，会产生非周向且不可预测的PDT反应。
