一种用于犬类模型中食管癌光动力治疗的定心球囊。

A centering balloon for photodynamic therapy of esophageal cancer tested in a canine model.

作者信息

Overholt B F, DeNovo R C, Panjehpour M, Petersen M G

机构信息

Laser/Hyperthermia Department, Thompson Cancer Survival Center, University of Tennessee, Knoxville.

出版信息

Gastrointest Endosc. 1993 Nov-Dec;39(6):782-7. doi: 10.1016/s0016-5107(93)70265-5.

DOI:10.1016/s0016-5107(93)70265-5

PMID:8293901

Abstract

Delivery of uniform circumferential light is desirable during photodynamic therapy of early or advanced esophageal cancer in human beings. Studies were performed in the canine esophagus to investigate whether use of a centering balloon would improve circumferential illumination of esophageal mucosa for photodynamic therapy of esophageal cancer. When the centering balloon was used, photodynamic therapy produced uniform and circumferential injury. With the cylindrical diffuser used in human studies, non-uniform and focal esophageal injury occurred. Placement of isotropic probes on the balloon wall allowed measurement and verification of relatively uniform light doses delivered to esophageal mucosa during balloon photodynamic therapy. The centering balloon has a potential role in improving light dosimetry during esophageal photodynamic therapy.

摘要

在人类早期或晚期食管癌的光动力治疗过程中，实现均匀的周向光照是很有必要的。在犬食管上进行了研究，以调查使用定心球囊是否会改善食管癌光动力治疗中食管黏膜的周向照明。当使用定心球囊时，光动力治疗产生了均匀的周向损伤。在人体研究中使用圆柱形扩散器时，出现了不均匀的局灶性食管损伤。在球囊壁上放置各向同性探头，可以测量和验证在球囊光动力治疗期间传递到食管黏膜的相对均匀的光剂量。定心球囊在改善食管光动力治疗期间的光剂量测定方面具有潜在作用。