Murrer, Department of Clinical Physics, Dr. Daniel Den Hoed Cancer Centre, Erasmus University Hospital, P.O. Box 5201, 3008 AE, Rotterdam, The Netherlands.
Lasers Med Sci. 1997 Oct;12(3):253-9. doi: 10.1007/BF02765106.
This paper presents a design of an applicator for light delivery and light dosimetry during endobronchial photodynamic therapy (EB-PDT). The design incorporates a linear diffuser that is fixed in the centre of the lumen by a steel spring basket that does not block air flow. An isotropic light detector is included in this design, to measure the light fluence actually delivered to the bronchial mucosa surface. The applicator is designed for use with common bronchoscopy equipment, and can be used with bronchoscopes with a large biopsy channel ( approximately 3 mm). The first clinical measurements were performed and caused no additional discomfort to the (nonphotosensitized) patients. The data showed considerable inter-patient variability of the light fluence rate measured as a result of fixed output power of the diffuser. This fact and the expected strong dependence of the fluence rate on the lumen diameter stress the importance of in situ fluence rate measurement for a proper evaluation of the relationship between light fluence and the biological response of EB-PDT.
本文提出了一种用于支气管内光动力疗法（EB-PDT）中光传递和光剂量测量的施源器设计。该设计采用线性扩散器，通过不阻挡气流的钢篮固定在管腔中心。该设计还包括一个各向同性的光探测器，用于测量实际输送到支气管黏膜表面的光剂量。该施源器专为与普通支气管镜设备一起使用而设计，可与具有大活检通道（约 3 毫米）的支气管镜一起使用。已进行了首次临床测量，并未给（未敏化的）患者带来额外不适。数据显示，由于扩散器的固定输出功率，测量的光剂量率存在相当大的患者间可变性。这一事实以及剂量率对管腔直径的强烈依赖性，强调了在适当评估光剂量与 EB-PDT 生物学反应之间关系时，进行原位剂量率测量的重要性。
