Barker P B, Bryan R N, Kumar A J, Naidu S
Department of Radiology, Johns Hopkins Hospital, Baltimore, MD 21205.
Neuropediatrics. 1992 Oct;23(5):263-7. doi: 10.1055/s-2008-1071355.
Proton Nuclear Magnetic Resonance (NMR) spectroscopy was used to quantitatively determine cerebral N-Acetyl Aspartate (NAA) concentrations in four patients with Canavan's disease and in four age-matched control subjects. Macroscopic NAA concentrations (mumol/gm wet weight) were not found to be significantly different from controls. Reduced levels of choline and creatine were observed in all patients, and increased levels of lactate and inositol in the eldest three patients.
采用质子核磁共振（NMR）光谱法对4例患有卡纳万病的患者及4例年龄匹配的对照者的脑N-乙酰天门冬氨酸（NAA）浓度进行了定量测定。未发现患者的宏观NAA浓度（微摩尔/克湿重）与对照组有显著差异。所有患者均观察到胆碱和肌酸水平降低，年龄最大的3例患者乳酸和肌醇水平升高。
