Chang H N
Department of Chemical Engineering. Korea Advanced Institute of Science and Technology, PO Box 131 Dongdaemun, Seoul, Korea.
Biotechnol Adv. 1987;5(1):129-45. doi: 10.1016/0734-9750(87)90007-3.
Membrane bioreactors have in-situ separation capability lacking in other types of immobilized cell reactors. This makes them very useful for certain systems. Enzyme reactions utilizing cofactors and hydrolysis of macromolecules are advantageous in membrane reactors. Anaerobic cell culture may be efficiently carried out in membrane cell recycle systems, while aerobic cultures work well in dual hollow fiber reactors. Animal and plant cells have much a better chance of success in membrane reactors because of the protective environment of the reactor and the small oxygen uptake rate of these cells.
膜生物反应器具有其他类型固定化细胞反应器所缺乏的原位分离能力。这使得它们在某些系统中非常有用。利用辅因子的酶反应和大分子的水解在膜反应器中具有优势。厌氧细胞培养可以在膜细胞循环系统中高效进行，而需氧培养在双中空纤维反应器中效果良好。由于反应器的保护环境以及这些细胞较低的氧气摄取率，动植物细胞在膜反应器中成功的机会要大得多。
