Barrios-González J, González H, Mejía A
Depto. de Biotecnología, Universidad Autónoma Metropolitana, Iztapalapa, Apdo. Postal 55-535, 09340, México.
Biotechnol Adv. 1993;11(3):539-47. doi: 10.1016/0734-9750(93)90022-f.
The use of a large particle size (14 mm) support (sugar cane bagasse) increased penicillin production by solid state fermentation by 37 %, however this effect was due to a higher sugar concentration in this bagasse fraction. Cultures with closer packing densities (0.35) produced 20 % more penicillin. Agitation did not have a negative effect on production if moisture loss during the operation is restituted.
