Ricketts A P, Dirlam J P, Shively J E
Central Research Division, Pfizer Inc, Groton, Connecticut 06340.
Poult Sci. 1992 Oct;71(10):1631-6. doi: 10.3382/ps.0711631.
The current study investigated the anticoccidial activity of the ionophore CP-84,657 against laboratory strains of the five major pathogenic species of Eimeria that infect poultry. Based on lesion scores and weight gain, the ionophore CP-84,657 achieved broad-spectrum anticoccidial efficacy in battery trials at doses of 4 and 5 ppm that was equivalent to reference commercial ionophores. In uninfected chickens, 4 ppm of CP-84,657 was the highest dose that gave growth rate and feed efficiency equivalent to commercial agents over 21 days in batteries and 49 days in floor pens. Ionophore CP-84,657 is an efficacious, well-tolerated anticoccidial in chickens, with potency comparable to that of the most potent known ionophores.
本研究调查了离子载体CP - 84,657对感染家禽的五种主要致病性艾美耳球虫实验室菌株的抗球虫活性。基于病变评分和体重增加情况，离子载体CP - 84,657在剂量为4 ppm和5 ppm时，在笼养试验中达到了与参考商业离子载体相当的广谱抗球虫效果。在未感染的鸡中，4 ppm的CP - 84,657是在笼养条件下21天以及地面平养条件下49天内，能使生长速率和饲料效率与商业制剂相当的最高剂量。离子载体CP - 84,657在鸡中是一种有效的、耐受性良好的抗球虫药，其效力与已知最强效的离子载体相当。
