Kantor S, Schenkel R H
Poult Sci. 1984 Aug;63(8):1497-505. doi: 10.3382/ps.0631497.
The anticoccidial activity of CL 259,971, a new polyether ionophore produced by Actinomadura yumaense sp. nov, has been demonstrated against six species of poultry Eimeria, tested individually or in mixed species infections. Statistically significant activity was obtained against some species with as little as 2.5 ppm of drug. The optimal treatment level, however, was determined to be 5 ppm. At this level, performance was comparable to 100 or 120 ppm of monensin. CL 259,971 is coccidiocidal and affects the early asexual stages of the life cycle of E. tenella. Fed to uninoculated cockerels in batteries at 10 ppm for 7 weeks, CL 259,971 permitted numerically superior weight gains when compared with 200 ppm of monensin.
由新种尤马马杜拉放线菌产生的新型聚醚离子载体CL 259,971的抗球虫活性已在六种家禽艾美耳球虫上得到证实，这些球虫单独或混合感染进行测试。对某些球虫种类，低至2.5 ppm的药物就能产生统计学上显著的活性。然而，最佳治疗水平确定为5 ppm。在此水平下，性能与100或120 ppm的莫能菌素相当。CL 259,971具有杀球虫作用，并影响柔嫩艾美耳球虫生命周期的早期无性阶段。以10 ppm的剂量饲喂电池笼中未接种的小公鸡7周后，与200 ppm的莫能菌素相比，CL 259,971使体重增加在数量上更优。
