Hughes Michael A, Wang Alice, DeWeese Theodore L
Department of Radiation Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Urology. 2003 Oct;62(4):748. doi: 10.1016/s0090-4295(03)00669-1.
We report a case of a 50-year-old man with two synchronous second malignancies 25 years after orchiectomy and adjuvant radiotherapy for seminoma. An annual health examination revealed an elevated prostate-specific antigen level. A biopsy was performed revealing Gleason score 9 adenocarcinoma of the prostate. Computed tomography of the abdomen revealed a 2-cm solid mass in the right kidney consistent with renal cell carcinoma. Both of these lesions were within the nonstandard radiation field for seminoma with which this patient was treated. Second malignancies, including prostate cancer, are a very uncommon occurrence but an important consideration in long-term survivors of seminoma treated with radiotherapy.
我们报告一例50岁男性患者，在因精原细胞瘤接受睾丸切除术后辅助放疗25年时出现了两种同时发生的第二原发恶性肿瘤。年度健康检查发现前列腺特异性抗原水平升高。活检显示为Gleason评分9分的前列腺腺癌。腹部计算机断层扫描显示右肾有一个2厘米的实性肿块，符合肾细胞癌。这两个病变均位于该患者接受治疗的精原细胞瘤的非标准放疗野内。包括前列腺癌在内的第二原发恶性肿瘤非常罕见，但对于接受放疗的精原细胞瘤长期存活者来说是一个重要的考虑因素。
