Biermann C W, Fröschle G, Kuhlencordt R, Schwarz R, Gonnermann D
Abteilung für Allgemeinchirurgie, Universitätskrankenhaus Eppendorf, Hamburg.
Helv Chir Acta. 1994 Dec;60(6):1131-6.
Malignancies of the biliary tract are rare diseases. Tumor inductions after radiotherapy are reported in several papers. We report about 3 cases with consecutive biliary tract carcinoma 18-32 years after manifestation of an urogenital carcinoma. All 3 patients (52-63 years) were treated with additive radiotherapy after surgical-urological therapy. Icterus was the top-ranging symptom of this secondary carcinoma. In 2 of the 3 cases surgical tumor resection was performed (biliary duct resection with central liver resection; pancreatico-duodenectomy). Because of the bad general condition of health the third patient got only a biopsy of the tumor. All patients died within 2 years after diagnosis. The accidental accumulation of the rare biliary tract carcinoma after urogenital malignancies in our collection of clinical cases (2 seminoma; 1 bladder tumor) give rise the question about the causal association between primary carcinoma, additive therapy and the development of secondary carcinoma.
胆道恶性肿瘤是罕见疾病。多篇论文报道了放疗后的肿瘤诱发情况。我们报告了3例在泌尿生殖系统癌出现18至32年后相继发生胆道癌的病例。所有3例患者（年龄52至63岁）在接受外科泌尿治疗后均接受了辅助放疗。黄疸是这种继发性癌最常见的症状。3例中的2例进行了手术肿瘤切除（胆管切除加肝中央切除；胰十二指肠切除术）。由于健康状况不佳，第3例患者仅接受了肿瘤活检。所有患者在诊断后2年内死亡。在我们收集的临床病例（2例精原细胞瘤；1例膀胱肿瘤）中，泌尿生殖系统恶性肿瘤后罕见地相继出现胆道癌，这引发了关于原发性癌、辅助治疗与继发性癌发生之间因果关系的问题。
