Arnett F C, Reveille J D
Division of Rheumatology and Clinical Immunogenetics, University of Texas Medical School, Houston.
Rheum Dis Clin North Am. 1992 Nov;18(4):865-92.
Systemic lupus erythematosus (SLE) is a complex autoimmune disease in which multiple genes appear to play important roles in pathogenesis. Hereditary deficiencies, both complete and partial, of several components of the complement system clearly predispose to lupus. HLA class II alleles appear to mediate specific autoantibodies, many of which are pathogenic. Modern molecular techniques are now providing insight into the specific major histocompatibility complex class II polymorphisms that are associated with different autoantibodies in SLE. Other genetic systems also may be important.
系统性红斑狼疮（SLE）是一种复杂的自身免疫性疾病，其中多个基因似乎在发病机制中起重要作用。补体系统的几个成分存在遗传性缺陷，包括完全缺陷和部分缺陷，这显然易患狼疮。HLA II类等位基因似乎介导特定的自身抗体，其中许多具有致病性。现代分子技术现在正在深入了解与SLE中不同自身抗体相关的特定主要组织相容性复合体II类多态性。其他遗传系统也可能很重要。
