Huikko Katri, Kostiainen Risto, Kotiaho Tapio
Department of Pharmacy, PO Box 56, FIN-00014 University of Helsinki, Helsinki, Finland.
Eur J Pharm Sci. 2003 Oct;20(2):149-71. doi: 10.1016/s0928-0987(03)00147-7.
This review presents a brief overview of recent developments in miniaturization of analytical instruments utilizing microfabrication technology. The concept 'Micro-Total Analysis Systems micro-TAS)', also termed 'Lab-on-a-chip', and the latest progresses in the development of microfabricated separation devices and on-chip detection techniques are discussed. Applications of micro-analytical methods to bioanalytical and pharmaceutical studies are also described, including chemical reactions, assays, and analytical separations of biomolecules in micro-scale.
本综述简要概述了利用微制造技术实现分析仪器小型化的最新进展。讨论了“微全分析系统（μ-TAS）”这一概念，也称为“芯片实验室”，以及微制造分离装置和芯片上检测技术的最新进展。还描述了微分析方法在生物分析和药物研究中的应用，包括微观尺度下生物分子的化学反应、分析测定和分析分离。
