Nyholm Leif
Department of Materials Chemistry, The Angström Laboratory, Uppsala, Sweden.
Analyst. 2005 May;130(5):599-605. doi: 10.1039/b415004j.
During the last few years there has been a rapid increase in the use of electrochemical reactions in lab-on-a-chip devices. This development, which has so far mainly focussed on electrochemical detection in chip-based capillary electrophoresis, can be explained by the fact that electrochemical techniques and devices are particularly well-suited for inclusion in lab-on-a-chip systems. The most important reason for this is that the required electrodes can readily be manufactured and miniaturised without loss of analytical performance using conventional microfabrication methods. In this Research Highlight article, the developments during the last three years concerning electrochemical techniques for lab on-a-chip applications are discussed, with particular focus on emerging electrochemical methods for sample clean-up and preconcentration, electrochemical derivatisation and electrochemical detection in chip-based capillary electrophoresis.
在过去几年中，芯片实验室设备中电化学反应的应用迅速增加。到目前为止，这一发展主要集中在基于芯片的毛细管电泳中的电化学检测，其原因在于电化学技术和设备特别适合集成到芯片实验室系统中。最重要的原因是，使用传统微加工方法可以很容易地制造和小型化所需电极，而不会损失分析性能。在这篇研究亮点文章中，讨论了过去三年中用于芯片实验室应用的电化学技术的发展，特别关注用于样品净化和预浓缩的新兴电化学方法、电化学衍生化以及基于芯片的毛细管电泳中的电化学检测。
