Lindqvist U, Laurent T C
Department of Clinical Chemistry, University Hospital, Uppsala, Sweden.
Scand J Clin Lab Invest. 1992 Nov;52(7):613-21. doi: 10.3109/00365519209115504.
The serum levels of hyaluronan and the aminoterminal propeptide of Type III procollagen (PIIINP) were compared in 585 healthy individuals as a function of age. Newborn children displayed high hyaluronan (695 +/- 634 micrograms l-1, mean +/- SD) and PIIINP (295 +/- 152 micrograms l-1) values. The values were not correlated to the gestational week in which the children were born or to the birth weight but there was a significant correlation (p < 0.05) between the hyaluronan and PIIINP levels. During the first year the levels dropped and in childhood (1-16 years of age) both hyaluronan and PIIINP levels were fairly constant at 27 +/- 16 and 22 +/- 8.4 micrograms l-1, respectively. The PIIINP level showed a marked drop in adults compared to children. The drop continued to about 50 years of age (6.5 +/- 2.2 micrograms l-1) and then there was a slight increase in elderly people. The hyaluronan showed a continued increase with age from the level at 16 years of 29 +/- 17 micrograms l-1 to a mean value of 177 +/- 133 micrograms l-1 in people over 75 years. There was no increase in serum hyaluronan in women during pregnancy but the PIINP level increased in the later part of the gestational period. There was no correlation between the serum values of hyaluronan and PIIINP when compared throughout the life span which indicates that the blood levels of the two markers are regulated by independent factors.
在585名健康个体中，比较了透明质酸和III型前胶原氨基端前肽（PIIINP）的血清水平与年龄的关系。新生儿的透明质酸（695±634微克/升，均值±标准差）和PIIINP（295±152微克/升）水平较高。这些值与孩子出生时的孕周或出生体重无关，但透明质酸和PIIINP水平之间存在显著相关性（p<0.05）。在第一年中，这些水平下降，在儿童期（1至16岁），透明质酸和PIIINP水平分别相当稳定在27±16和22±8.4微克/升。与儿童相比，成年人的PIIINP水平显著下降。这种下降持续到约50岁（6.5±2.2微克/升），然后老年人略有增加。透明质酸从16岁时的29±17微克/升水平随年龄持续增加，在75岁以上人群中均值为177±133微克/升。女性在怀孕期间血清透明质酸没有增加，但PIIINP水平在孕期后期增加。在整个生命周期中比较时，透明质酸和PIIINP的血清值之间没有相关性，这表明这两种标志物的血液水平受独立因素调节。
