Perico A, Lorini C, Biliotti T, Bavazzano P, Lanciotti E
Lab. di Sanità Pubblica, Azienda Sanitaria di Firenze.
Ann Ig. 2003 Jul-Aug;15(4):363-71.
The aim of this study, carried out from 1997 to 2000, was to evaluate the exposure to antiblastic drugs of hospital staff (38 nurses of 7 oncological Day Hospital care in Tuscany). To evaluate the internal exposure was used biological monitoring, in particular was determined the concentration of urinary cyclophosfamide (CF); pad was made to evaluate the skin contamination. The contamination of working surfaces was determinate, by wipe-test, to verify the decontamination procedures; were used, as markers, CF and 5-fluorouracil (5-FU). We assessed the permeability thorough gloves usually used by the staff and the degradative activity to these drugs by agents used to decontaminate the working surfaces. The results shows, in urine, value lower than the detection limits, although was found a diffused contamination of the working environment. The results confirmed that NaClO is the best product to decontaminate working surfaces and nitrile gloves the ones with less permeability.
本研究于1997年至2000年开展，旨在评估医院工作人员（托斯卡纳7家肿瘤日间医院护理部门的38名护士）对抗癌药物的接触情况。为评估体内接触情况，采用了生物监测，尤其测定了尿中环磷酰胺（CF）的浓度；还进行了皮肤污染评估。通过擦拭试验确定工作表面的污染情况，以验证去污程序；使用CF和5-氟尿嘧啶（5-FU）作为标志物。我们评估了工作人员通常使用的手套的通透性以及用于清洁工作表面的试剂对这些药物的降解活性。结果显示，尿液中的值低于检测限，不过发现工作环境存在普遍污染。结果证实，次氯酸钠是清洁工作表面的最佳产品，而腈手套的通透性最低。
