Miraglia N, Castiglia L, Muselli A, Astarita S, Acampora A, Sannolo N
Dipartimento di Medicina Sperimentale, Sezione di Medicina del Lavoro, Igiene e Tossicologia Industriale, Seconda Università degli Studi di Napoli, Via L. De Crecchio, 80138 Napoli.
G Ital Med Lav Ergon. 2007 Jul-Sep;29(3 Suppl):739-40.
An environmental monitoring strategy was carried out for the determination of surface concentrations of cyclophosphamide (CP), ifosfamide (IF) and 5-fluorouracil (5-FU) in a drug preparation room of an oncology ward. Analytes were determined by wipe tests, liquid-liquid extraction with diatomaceous earths and GC/MSMS or HPLC/UV analysis. The analysed 249 samples showed concentrations of CP, IF and 5-FU varying in the ranges 0.020-18.83, 0.100-26.96, 0.740-208.9 microg/dm2, respectively. It is noteworthy that the 9.3% (CP), 18.6% (IF) and 76.3% (5-FU) of the investigated surfaces showed high contamination levels, with analytes amount higher than 0.5 microg/dm2 and a progressive contamination decrement going from workbenches, floor, hood planes and other examined surfaces (interphone, telephone etc.). A significant correlation (rhos = 0.303, p = 0.001) between the measured analyte concentration and the analyte handled amount was found only in the case of IF, and a diffuse contamination (traces of all the three analytes) was found on all investigated surfaces, even when analytes were not been used during the sampling days.
在一个肿瘤病房的药物配制室进行了一项环境监测策略，以测定环磷酰胺（CP）、异环磷酰胺（IF）和5-氟尿嘧啶（5-FU）的表面浓度。通过擦拭试验、用硅藻土进行液液萃取以及气相色谱/串联质谱（GC/MSMS）或高效液相色谱/紫外（HPLC/UV）分析来测定分析物。所分析的249个样本显示，CP、IF和5-FU的浓度范围分别为0.020 - 18.83、0.100 - 26.96、0.740 - 208.9微克/平方分米。值得注意的是，9.3%（CP）、18.6%（IF）和76.3%（5-FU）的被调查表面显示出高污染水平，分析物含量高于0.5微克/平方分米，并且从工作台、地板、通风橱平面和其他检查表面（对讲机、电话等）呈现出逐渐降低的污染程度。仅在IF的情况下，发现测量的分析物浓度与分析物处理量之间存在显著相关性（rhos = 0.303，p = 0.001），并且在所有被调查表面都发现了弥漫性污染（所有三种分析物的痕迹），即使在采样日未使用分析物的情况下也是如此。
