Borg G, Allander E, Lund B, Berg E, Brodin U, Pettersson H, Trang L
Department of Social Medicine, Karolinska Institute, Huddinge University Hospital, Huddinge, Sweden.
J Rheumatol. 1988 Dec;15(12):1747-54.
The effect of early initiation of auranofin (AF) therapy on outcome measures was studied in a controlled 24-month double blind trial in 138 patients with early rheumatoid arthritis (RA) using an intent to treat approach. Patients were randomized to AF or placebo but in case of insufficient effect or intolerable adverse events, they switched to open disease modifying antirheumatic drug therapy. Patients who started AF fared significantly better in improved joint swelling. Stanford Health Assessment Questionnaire index, Keitel functional test, and mental depression, and furthermore, radiologic progression was significantly retarded. Our results support a disease modifying beneficial effect of AF in early active RA.se
在一项针对138例早期类风湿性关节炎（RA）患者的为期24个月的对照双盲试验中，采用意向性治疗方法研究了早期开始使用金诺芬（AF）治疗对结局指标的影响。患者被随机分为接受AF或安慰剂治疗，但如果效果不佳或出现无法耐受的不良事件，则改用开放标签的改善病情抗风湿药物治疗。开始使用AF治疗的患者在关节肿胀改善、斯坦福健康评估问卷指数、凯特尔功能测试和精神抑郁方面的表现明显更好，此外，放射学进展也明显减缓。我们的结果支持AF在早期活动性RA中具有改善病情的有益作用。
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