de Boer W P H, Oudejans J J, Meijer C J L M, Lankelma J
Department of Medical Oncology, VU Medical Center, PO Box 7057, 1081 Hv Amsterdam, The Netherlands.
Bioinformatics. 2003 Oct 12;19(15):2000-1. doi: 10.1093/bioinformatics/btg267.
Unravelling overlapping clusters of functionally linked genes is a major challenge to current clustering programs. Algorithm GRANK permits systematic study of overlap between clusters of genes of a similar expression profile and large variation across a series of microarrays.
GRANK is freely available from http://www.bio.vu.nl/microb/research/tumor.html provided one adheres to the end-user license agreement in the associated manual.
Above website also supplies the in- and output files used in the example run.
解析功能相关基因的重叠簇是当前聚类程序面临的一项重大挑战。GRANK算法允许对具有相似表达谱的基因簇之间的重叠以及一系列微阵列中的大变异进行系统研究。
只要遵守相关手册中的最终用户许可协议，GRANK可从http://www.bio.vu.nl/microb/research/tumor.html免费获取。
上述网站还提供了示例运行中使用的输入和输出文件。
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