Pakulska Wanda, Wejman Irena, Czarnecka Elzbieta
Department of Pharmacodynamics, Medical University of Łódź, 1 Muszyńskiego Str., 90-151 Łódź, Poland.
Acta Pol Pharm. 2003 May-Jun;60(3):201-6.
The influence of felbamate (200 mg/kg or 50 mg/kg) on antinociceptive effect of morphine (10 mg/kg), metamizol (500 mg/kg) and indomethacin (10 mg/kg or 1.4 mg/kg) was investigated in a mouse model using the hot-plate test. All drugs were injected intraperitoneally. Felbamate was administered to mice 30 min before applying the analgesic drugs. Measurement of nociception was performed within 2 h after felbamate administration. The research studies were further conducted with a multiple (10 days) drug dosage. Felbamate in the dose of 200 mg/kg significantly increases the analgesic effect of morphine and weakens the effect of metamizol and indomethacin. Multiple administration of felbamate does not affect the activity of morphine and metamizol, but decreases analgesic effect of indomethacin.
在小鼠模型中，采用热板试验研究了非氨酯（200毫克/千克或50毫克/千克）对吗啡（10毫克/千克）、安乃近（500毫克/千克）和吲哚美辛（10毫克/千克或1.4毫克/千克）镇痛作用的影响。所有药物均腹腔注射。在应用镇痛药物前30分钟给小鼠给予非氨酯。在给予非氨酯后2小时内进行痛觉测量。研究进一步采用多次（10天）给药剂量进行。200毫克/千克剂量的非氨酯显著增强吗啡的镇痛作用，并减弱安乃近和吲哚美辛的作用。多次给予非氨酯不影响吗啡和安乃近的活性，但会降低吲哚美辛的镇痛作用。
