米安色林对小鼠体内吗啡、安乃近和吲哚美辛镇痛作用的影响。

Influence of mianserin on the antinociceptive effect of morphine, metamizol and indomethacin in mice.

作者信息

Pakulska W, Czarnecka E

机构信息

Department of Pharmacodynamics, Chair of Pharmacology, Medical University of Lódź, 1 Muszyńskieocediloo Street, Poland.

出版信息

Pharmacol Res. 2002 Nov;46(5):415-23. doi: 10.1016/s1043661802001299.

DOI:10.1016/s1043661802001299

PMID:12419646

Abstract

The influence of mianserin (5 or 3.6mgkg(-1)) on antinociceptive effect of morphine (10mgkg(-1)), metamizol (500mgkg(-1)) and indomethacin (10 or 1.4mgkg(-1)) was investigated in a mouse model using the tail-flick and hot-plate tests. All drugs were injected intraperitoneally (i.p.). Mianserin was administered to mice 30min before applying the analgesic drugs. Measurement of nociception was performed within 2h after mianserin administration. The study was further conducted for 14 days with multiple drug doses. The results indicate that mianserin in a single dose increased the antinociceptive effect of metamizol (in the hot-plate and tail-flick tests) and indomethacin (only in the tail-flick test). Mianserin administered for 14 days together with metamizol increased the analgesic effect of the latter drug (in the hot-plate and tail-flick tests). Mianserin applied for 14 days increased the antinociceptive effect of indomethacin (in the tail-flick test).

摘要

在小鼠模型中，使用甩尾试验和热板试验研究了米安色林（5或3.6mgkg(-1)）对吗啡（10mgkg(-1)）、安乃近（500mgkg(-1)）和吲哚美辛（10或1.4mgkg(-1)）镇痛作用的影响。所有药物均通过腹腔注射（i.p.）给药。在给予镇痛药物前30分钟给小鼠注射米安色林。在米安色林给药后2小时内进行痛觉测量。该研究使用多种药物剂量进一步进行了14天。结果表明，单剂量的米安色林增强了安乃近（在热板试验和甩尾试验中）和吲哚美辛（仅在甩尾试验中）的镇痛作用。与安乃近一起给药14天的米安色林增强了后一种药物的镇痛效果（在热板试验和甩尾试验中）。应用14天的米安色林增强了吲哚美辛的镇痛作用（在甩尾试验中）。