Pakulska Wanda, Czarnecka Elzbieta
Department of Pharmacodynamics, Medical University of Lódź, 1 Muszyńskiego Str., 90-151 Lódź, Poland.
Acta Pol Pharm. 2004 Sep-Oct;61(5):393-400.
The effect of gabapentin at a dose of 10 mg/kg (single administration) and at 3 mg/kg/day (administered for 10 days) on the analgesic action of morphine (10 mg/kg), metamizol (500 mg/kg) and indomethacin (10 mg/kg and 1.4 mg/kg) in mice was assessed on the basis of hot-plate and tail-flick tests. All the drugs were administered intraperitoneally (i.p.). Gabapentin was administered to mice 30 min before the administration of analgesics. The animals reactions to noxious stimuli were measured 60, 90 and 120 min after gabapentin administration. Gabapentin administered in a single dose, as well as in multiple ones, was found to cause antinociception, especially evident in the hot-plate test. The single dose of gabapentin enhances the analgesic effect of morphine in the hot-plate test, whereas in the tail-flick test it demonstrates an opposite effect. Gabapentin in a single dose does not affect significantly the effects of metamizol and indomethacin, whereas multiple doses decrease the action of these drugs. Gabapentin abolishes the tolerance of antinociceptive effect of morphine.
基于热板法和甩尾试验，评估了剂量为10mg/kg（单次给药）和3mg/kg/天（给药10天）的加巴喷丁对小鼠体内吗啡（10mg/kg）、安乃近（500mg/kg）和吲哚美辛（10mg/kg和1.4mg/kg）镇痛作用的影响。所有药物均通过腹腔注射给药。在给予镇痛药前30分钟给小鼠注射加巴喷丁。在注射加巴喷丁后60、90和120分钟测量动物对有害刺激的反应。发现单次给药以及多次给药的加巴喷丁均能引起抗伤害感受，在热板试验中尤为明显。在热板试验中，单次剂量的加巴喷丁可增强吗啡的镇痛效果，而在甩尾试验中则表现出相反的效果。单次剂量的加巴喷丁对安乃近和吲哚美辛的效果无显著影响，而多次给药则会降低这些药物的作用。加巴喷丁可消除吗啡抗伤害感受作用的耐受性。
