Lee Jennifer H, Chan Jean L, Yiannakouris Nikos, Kontogianni Meropi, Estrada Elizabeth, Seip Richard, Orlova Christine, Mantzoros Christos S
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
J Clin Endocrinol Metab. 2003 Oct;88(10):4848-56. doi: 10.1210/jc.2003-030519.
Resistin is a novel adipocyte-secreted hormone proposed to link obesity with diabetes. Studies in mice have revealed conflicting data however, and the physiological role of circulating resistin in humans remains unknown. We conducted cross-sectional studies in 123 middle-aged women and 120 healthy young subjects and found that serum resistin levels did not correlate with markers of adiposity, including body mass index, waist-to-hip ratio, or fat mass, or insulin resistance assessed by homeostasis model, lipid profile, or serum leptin levels; but females had higher resistin levels than males (P < 0.02). We also found no difference in serum resistin levels between lean healthy and obese insulin-resistant nondiabetic and type 2 diabetic adolescents. Finally, to evaluate the effect of food deprivation and/or leptin administration on resistin levels, we performed interventional studies that revealed no significant difference in resistin levels after 48 h of fasting and/or leptin administration at either physiological or pharmacological doses. We conclude that circulating resistin is unlikely to play a major role in insulin resistance or energy homeostasis in humans.
抵抗素是一种新发现的由脂肪细胞分泌的激素，被认为与肥胖和糖尿病之间存在关联。然而，小鼠研究得出的数据相互矛盾，循环抵抗素在人类中的生理作用仍然未知。我们对123名中年女性和120名健康年轻受试者进行了横断面研究，发现血清抵抗素水平与肥胖指标（包括体重指数、腰臀比或脂肪量）以及通过稳态模型评估的胰岛素抵抗、血脂谱或血清瘦素水平均无相关性；但女性的抵抗素水平高于男性（P < 0.02）。我们还发现，健康瘦体型、肥胖胰岛素抵抗非糖尿病以及2型糖尿病青少年的血清抵抗素水平没有差异。最后，为了评估食物剥夺和/或给予瘦素对抵抗素水平的影响，我们进行了干预研究，结果显示在禁食48小时和/或给予生理或药理剂量的瘦素后，抵抗素水平没有显著差异。我们得出结论，循环抵抗素不太可能在人类胰岛素抵抗或能量稳态中起主要作用。
