Ramya Dasari, Raghunath Vandana, Krishna Polisetty Siva, Kamal Firoz, Aparna Latha H
Department of Oral Pathology and Microbiology, Navodaya Dental College and Hospital, Raichur, Karnataka, India.
Department of Oral Pathology and Microbiology, Narayana Dental College and Hospital, Nellore, Andhra Pradesh, India.
J Oral Maxillofac Pathol. 2025 Apr-Jun;29(2):254-259. doi: 10.4103/jomfp.jomfp_219_24. Epub 2025 Jun 30.
Diabetes mellitus represents a significant health concern, projected to impact 449 million individuals worldwide by the year 2030. The factors linking obesity and insulin resistance (IR) have been an emerging topic of research, owing to the novel group of factors discovered, the "adipocytokines". One such inflammatory adipocytokine is Resistin, which has been crucial to the development of (IR), which subsequently leads to type II diabetes mellitus (T2DM), due to its significant pro inflammatory properties. However, serological studies present conflicting evidence on resistin's link to obesity, IR, and T2DM and only one salivary study exists, with none in the Indian population. With saliva harboring many biomarkers, there lies a probability of resistin being labelled as one. It could facilitate earlyT2DM diagnosis and be monitored to prevent or delay complications. Thus, to unravel the enigmatic role of Resistin in T2DM, this study was undertaken.
Participants in the study were categorized into 2 groups, Group-I (T2DM), consisting of 30 newly diagnosed T2DM and Group- II (HC) with 30 healthy non-Diabetic participants. Serum and salivary resistin levels were measured using the Enzyme-linked Immunosorbent assay. Fasting blood sugar (FBS), HbA1C, and the inflammatory marker hs-CRP were assessed using Trinder's GOD/POD estimation, chromatographic and Turbidimetric Immuno assays respectively.
Higher mean values of serum resistin & salivary resistin were observed in Group I (T2DM) (10.5730 + 11.11936) & (10.2643 + 13.77515) compared to Group II (HC) individuals (6.4787 + 6.44202) & (3.7577 + 4.62597) respectively. It was statistically significant with a p value of 0.38 & 0.32 respectively.
However, no correlation could be established between the diabetic markers FBS, HbA1C, hs-CRP and serum or salivary resistin. A negative correlation (-0.208) was observed between serum & salivary resistin.
糖尿病是一个重大的健康问题，预计到2030年全球将有4.49亿人受其影响。由于发现了一组新的因素“脂肪细胞因子”，肥胖与胰岛素抵抗（IR）之间的关联因素一直是一个新兴的研究课题。抵抗素就是这样一种炎性脂肪细胞因子，由于其显著的促炎特性，它对胰岛素抵抗的发展至关重要，而胰岛素抵抗随后会导致II型糖尿病（T2DM）。然而，血清学研究关于抵抗素与肥胖、胰岛素抵抗和II型糖尿病之间的联系存在相互矛盾的证据，并且仅有一项唾液研究，而在印度人群中尚无相关研究。由于唾液中含有许多生物标志物，抵抗素有可能被列为其中之一。它可以促进II型糖尿病的早期诊断，并进行监测以预防或延缓并发症。因此，为了阐明抵抗素在II型糖尿病中的神秘作用，开展了本研究。
研究参与者分为两组，第一组（T2DM）由30名新诊断的II型糖尿病患者组成，第二组（HC）由30名健康的非糖尿病参与者组成。使用酶联免疫吸附测定法测量血清和唾液中的抵抗素水平。分别使用Trinder氏GOD/POD法、色谱法和比浊免疫测定法评估空腹血糖（FBS）、糖化血红蛋白（HbA1C）和炎症标志物高敏C反应蛋白（hs-CRP）。
与第二组（HC）个体（分别为6.4787 + 6.44202和3.7577 + 4.62597）相比，第一组（T2DM）中血清抵抗素和唾液抵抗素的平均值更高（分别为10.5730 + 11.11936和10.2643 + 13.77515）。其具有统计学意义，p值分别为0.38和0.32。
然而，糖尿病标志物FBS、HbA1C、hs-CRP与血清或唾液抵抗素之间未建立相关性。血清和唾液抵抗素之间观察到负相关（-0.208）。
