Amtage J, Schmidt W J
Neuropharmacology, Zoological Institute, University of Tuebingen, Auf der Morgenstelle 28E, 72076 Tuebingen, Germany.
Behav Pharmacol. 2003 Nov;14(7):563-7. doi: 10.1097/00008877-200311000-00009.
Haloperidol-induced catalepsy represents a model of neuroleptic-induced Parkinsonism. Daily administration of haloperidol, followed by testing for catalepsy on a bar and grid, results in a day-to-day increase in catalepsy that is completely context dependent, resulting in a strong placebo effect and in a failure of expression after a change in context. The aim of this study was to analyse the associative learning process that underlies context dependency. Catalepsy intensification was induced by a daily threshold dose of 0.25 mg/kg haloperidol. Extinction training and retesting under haloperidol revealed that sensitization was composed of two components: a context-conditioning component, which can be extinguished, and a context-dependent sensitization component, which cannot be extinguished. Context dependency of catalepsy thus follows precisely the same rules as context dependency of psychostimulant-induced sensitization. Catalepsy sensitization is therefore due to conditioning and sensitization.
氟哌啶醇诱导的僵住症是抗精神病药物所致帕金森综合征的一种模型。每日给予氟哌啶醇，随后在杆和网格上测试僵住症，结果显示僵住症会逐日增加，且完全依赖于环境，会产生强烈的安慰剂效应，并且在环境改变后表达失败。本研究的目的是分析构成环境依赖性基础的联想学习过程。通过每日给予0.25mg/kg的阈剂量氟哌啶醇诱导僵住症加剧。在氟哌啶醇作用下的消退训练和重新测试表明，敏化由两个成分组成：一个可消退的环境条件化成分和一个不可消退的环境依赖性敏化成分。因此，僵住症的环境依赖性与精神兴奋剂诱导的敏化的环境依赖性遵循完全相同的规则。因此，僵住症敏化是由于条件作用和敏化。
