Anagnostaras S G, Robinson T E
Department of Psychology, University of Michigan Ann Arbor 48109-1109, USA.
Behav Neurosci. 1996 Dec;110(6):1397-414. doi: 10.1037//0735-7044.110.6.1397.
The authors investigated the influence of associative pairing of contextual stimuli with amphetamine administration on the expression of psychomotor sensitization. Animals received d-amphetamine or saline in group-specific environments. Amphetamine produced robust behavioral sensitization in all environments, but when an amphetamine challenge was given in a test environment that was novel for some groups but not others, the expression of sensitization was completely context specific. An injection of saline in the amphetamine-paired environment produced a conditional response (CR), but this was quite small compared to the magnitude of the sensitized response, and sensitization remained completely context specific following extinction of the CR. Results are discussed in relation to 3 models of how context may modulate the expression of sensitization: an excitatory conditioning model, an inhibitory conditioning model, and an occasion-setting model.
作者研究了情境刺激与苯丙胺给药的联合配对对精神运动性敏感化表达的影响。动物在特定组的环境中接受d-苯丙胺或生理盐水。苯丙胺在所有环境中均产生强烈的行为敏感化，但当在对某些组来说是新环境而对其他组不是新环境的测试环境中给予苯丙胺激发时，敏感化的表达完全是情境特异性的。在与苯丙胺配对的环境中注射生理盐水会产生条件反应（CR），但与敏感化反应的强度相比，这相当小，并且在CR消退后敏感化仍然完全是情境特异性的。结合情境可能调节敏感化表达的三种模型讨论了结果：兴奋性条件作用模型、抑制性条件作用模型和情境设定模型。
