Roszkowska-Blaim M, Szymanik-Grzelak H
Kliniki Nefrologii Ak. Med. Warszawie.
Wiad Lek. 1992 Mar;45(5-6):197-200.
The sensitivity to Cefobid was evaluated in vitro in 37 bacterial strains obtained from 37 patients. Good effectiveness of the drug against the strains was found in 78.3%, moderate in 13.5%, none in 8.2%. The clinical examinations were carried out in 16 children and again a high clinical effectiveness of Cefobid was found, with cure in 14 cases (87.5%). Cefobid was ineffective in 2 children with infection of Tenckhoff catheter, which required finally exchange of the catheter. No side effects of Cefobid were noted. Cefobid is a safe and effective antibiotic which may be given to small children and patients with renal failure. The broad spectrum and the possibility of drug use without dosage modification facilitate the treatment of patients with various grades of renal failure.
对37例患者分离出的37株细菌进行了头孢哌酮体外敏感性评估。发现该药物对78.3%的菌株疗效良好，13.5%为中度有效，8.2%无效。对16名儿童进行了临床检查，再次发现头孢哌酮具有较高的临床疗效，14例治愈（87.5%）。2例Tenckhoff导管感染儿童使用头孢哌酮无效，最终需要更换导管。未观察到头孢哌酮的副作用。头孢哌酮是一种安全有效的抗生素，可用于儿童和肾衰竭患者。其广谱性以及无需调整剂量即可使用的可能性便于治疗不同程度肾衰竭的患者。
