Ito Michiko, Sakakura Akira, Miyazawa Naomi, Murata Shizuaki, Yoshikawa Kenichi
CREST of apan Science and Technology Corporation and Graduate School of Environmental Studies, School of Informatics and Sciences, Nagoya University, Chikusa, Nagoya, 464-8601, Japan.
J Am Chem Soc. 2003 Oct 22;125(42):12714-5. doi: 10.1021/ja036745x.
The all-or-none type DNA folding transition from a coil to globule can be differentiated by the chirality of the triamines. The fluorescent microscope observation on single DNA molecules makes it clear that the tripeptides obtained from naturally occurring basic amino acids (l-lysine or l-arginine) can compact DNA molecules at concentrations lower than those from d-isomers. Nanometer-sized beads are found in the AFM images on the folded DNA molecule.
三胺的手性可区分从卷曲到球状的全或无型DNA折叠转变。对单个DNA分子的荧光显微镜观察表明，由天然存在的碱性氨基酸（L-赖氨酸或L-精氨酸）获得的三肽能够在低于由D-异构体获得的三肽的浓度下使DNA分子致密化。在折叠DNA分子的原子力显微镜图像中发现了纳米尺寸的珠子。
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