Omlor G, Gross G, Ecker K W, Burger I, Feifel G
Department of Surgery, University of Saarland, Homburg/Saar, Federal Republic of Germany.
World J Surg. 1992 Nov-Dec;16(6):1117-9. doi: 10.1007/BF02067073.
During isolated limb perfusion, we studied the impact of limb temperature on the concentration of cytostatic drugs in the tissue to identify a possible selective absorption of cytostatic agents by the various tissues. Ten consecutive patients with malignant melanoma were randomly divided into two different groups and perfused with 1 mg cisplatin per kg body weight. In one group the cytostatic agents were injected under hyperthermic conditions (39.5 degrees C) and in the other group under normothermic conditions (37 degrees C). The platinum concentration in the melanoma was twice as high in the hyperthermic group as in the group under normothermic conditions. In the tumor-free tissue the platinum concentration decreased with temperature while it remained constant in the musculature. This selective concentration of cisplatin in the tumor under hyperthermic conditions is accompanied by fewer side effects. Follow-up will show whether the oncological results will be improved in the hyperthermic conditions as one might expect.
在离体肢体灌注过程中，我们研究了肢体温度对组织中细胞毒性药物浓度的影响，以确定各种组织对细胞毒性药物是否存在可能的选择性吸收。连续10例恶性黑色素瘤患者被随机分为两组，每千克体重灌注1毫克顺铂。一组在高温条件（39.5摄氏度）下注射细胞毒性药物，另一组在常温条件（37摄氏度）下注射。高温组黑色素瘤中的铂浓度是常温组的两倍。在无肿瘤组织中，铂浓度随温度降低，而在肌肉组织中保持恒定。高温条件下肿瘤中顺铂的这种选择性浓聚伴随着较少的副作用。随访将表明，正如人们所期望的那样，高温条件下的肿瘤学结果是否会得到改善。
