Kuipers Ernst J, Janssen Marcel J R, de Boer Wink A
Department of Gastroenterology and Hepatology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands.
Curr Opin Pharmacol. 2003 Oct;3(5):480-5. doi: 10.1016/s1471-4892(03)00116-4.
The discovery of Helicobacter pylori has had a major clinical impact. Clinical research is now focused on the role of H. pylori and H. pylori eradication in the treatment of several upper gastrointestinal disorders such as non-ulcer dyspepsia, ulceration during therapy with aspirin or other anti-inflammatory drugs, the treatment of precancerous conditions of the stomach, and the prevention of gastric cancer. Triple and quadruple therapies have become the standard for H. pylori eradication. The expansion of knowledge and the development of new therapeutic modalities are likely to lead to a further implementation of H. pylori-related methods in strategies for the prevention and treatment of upper gastrointestinal disorders.
幽门螺杆菌的发现产生了重大的临床影响。目前临床研究聚焦于幽门螺杆菌及其根除在治疗多种上消化道疾病中的作用，如非溃疡性消化不良、阿司匹林或其他抗炎药治疗期间的溃疡、胃部癌前病变的治疗以及胃癌的预防。三联和四联疗法已成为根除幽门螺杆菌的标准方法。知识的扩展和新治疗方式的发展可能会导致与幽门螺杆菌相关的方法在预防和治疗上消化道疾病的策略中得到进一步应用。
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