Wu J C Y, Sung J J Y
Division of Gastroenterology, Dept. of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, China.
Endoscopy. 2002 Feb;34(2):104-10. doi: 10.1055/s-2002-19843.
The literature on peptic ulcer and gastritis in 2000 again focused on the topics of Helicobacter pylori, nonsteroidal anti-inflammatory drugs (NSAIDs), and gastric cancer. New diagnostic tests for H. pylori infection have been evaluated, and rescue therapies for failed H. pylori eradication have been tested. The causal relationship between H. pylori infection and nonulcer dyspepsia, gastric cancer, gastroesophageal reflux disease, and NSAID-related ulcers remained heated topics of debate. In 2000, landmark clinical trials and meta-analyses were published addressing these issues. The role of endoscopy in managing nonulcer dyspepsia was better defined. The role of H. pylori eradication in NSAID/aspirin users was reexamined in high-risk patients. Clinical benefit was finally confirmed for specific inhibitors of cyclooxygenase-2 (COX-2). The millennium year turned out to be a very important one in the advancement of knowledge in this field.
2000年有关消化性溃疡和胃炎的文献再次聚焦于幽门螺杆菌、非甾体抗炎药（NSAIDs）和胃癌等主题。对幽门螺杆菌感染的新诊断测试进行了评估，并且对幽门螺杆菌根除失败的挽救疗法进行了试验。幽门螺杆菌感染与非溃疡性消化不良、胃癌、胃食管反流病以及NSAID相关溃疡之间的因果关系仍是激烈辩论的热门话题。2000年，针对这些问题发表了具有里程碑意义的临床试验和荟萃分析。内镜检查在管理非溃疡性消化不良中的作用得到了更好的界定。在高危患者中重新审视了幽门螺杆菌根除在NSAID/阿司匹林使用者中的作用。最终证实了环氧化酶-2（COX-2）特异性抑制剂的临床益处。事实证明，这一千年对于该领域知识的进步是非常重要的一年。
