Popova N K, Voitenko N N, Kulikov A V, Avgustinovich D F
Institute of Cytology and Genetics, Siberian Branch of the Academy of Science of the USSR, Novosibirsk.
Pharmacol Biochem Behav. 1991 Dec;40(4):751-6. doi: 10.1016/0091-3057(91)90080-l.
Silver foxes selected for more than 30 years for tame behavior and displaying no defensive reaction to human contact were shown to have a higher serotonin level in midbrain and hypothalamus, and a higher 5-hydroxyindole acetic acid (5-HIAA) content in midbrain, hypothalamus and hippocampus in comparison to nonselected wild silver foxes bred in captivity over the same time span. Tryptophan hydroxylase (TPH) activity in midbrain and hypothalamus in domesticated foxes was increased as compared with their aggressive/defensive counterparts. Monoamine oxidase type A (MAO A) activity was was decreased with an increased Km and unchanged Vmax in domesticated foxes. No changes in specific [3H]ketanserin or [3H]8-OH-DPAT binding in frontal cortex was revealed. A reduced density (Bmax) of 5HT1A receptors in hypothalamic membranes in domesticated foxes was shown. It is suggested that the brain serotonergic system is involved in the mechanism of domestication converting wild aggressive/defensive animals into tame ones.
经过30多年选育出的对人类接触无防御反应且行为温顺的银狐，与同期圈养的未经选育的野生银狐相比，中脑和下丘脑的血清素水平更高，中脑、下丘脑和海马体中的5-羟色胺乙酸（5-HIAA）含量更高。与具有攻击性/防御性的同类相比，家养狐狸中脑和下丘脑的色氨酸羟化酶（TPH）活性有所增加。家养狐狸的单胺氧化酶A（MAO A）活性降低，Km增加而Vmax不变。额叶皮层中特异性[3H]酮色林或[3H]8-羟基二苯丙氨酸（8-OH-DPAT）结合未显示出变化。家养狐狸下丘脑膜中5HT1A受体的密度（Bmax）降低。研究表明，大脑血清素能系统参与了将野生攻击性/防御性动物驯化为温顺动物的驯化机制。
