van der Valk Jolande C, van den Oord Edwin J C G, Verhulst Frank C, Boomsma Dorret I
Department of Biological Psychology, Vrije Universiteit, Van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.
J Am Acad Child Adolesc Psychiatry. 2003 Oct;42(10):1212-20. doi: 10.1097/00004583-200310000-00012.
To estimate genetic, shared environmental, and nonshared environmental contributions to stability and change in internalizing and externalizing problems.
Maternal Child Behavior Checklist ratings were obtained for 3,873 twin pairs at age 3 and 1,924 twin pairs at age 7. For 1,575 twin pairs, ratings were available at both ages.
For Internalizing/Externalizing ratings, genetic, shared, and nonshared environmental factors explained about 59/51%, 10/30%, and 31/19% of the variance at age 3, and 40/52%, 31/32%, and 29/16% of the variance at age 7. The phenotypic correlation of r = 0.38/0.54 between problems assessed at 3 and 7 years of age was explained for 66/55% by genetic factors, for 23/37% by shared environmental factors, and for 11/8% by nonshared environmental factors. The genetic, shared environmental, and nonshared environmental correlations between ages 3 and 7 were 0.51/0.57, 0.47/0.66, and 0.13/0.24, respectively.
Genetic and shared environmental factors were most important for the stability of Internalizing and Externalizing Problems between ages 3 and 7. Nonshared environmental factors were mainly age-specific. For Internalizing Problems, shared environment may become more important from early to middle childhood.
评估遗传、共享环境和非共享环境对内化问题和外化问题的稳定性及变化的影响。
获取了3873对双胞胎在3岁时以及1924对双胞胎在7岁时的母婴行为清单评分。对于1575对双胞胎,两个年龄段的评分均有。
对于内化/外化评分,遗传、共享和非共享环境因素在3岁时分别解释了约59/51%、10/30%和31/19%的方差,在7岁时分别解释了40/52%、31/32%和29/16%的方差。3岁和7岁时评估的问题之间r = 0.38/0.54的表型相关性,遗传因素解释了66/55%,共享环境因素解释了23/37%,非共享环境因素解释了11/8%。3岁和7岁之间的遗传、共享环境和非共享环境相关性分别为0.51/0.57、0.47/0.66和0.13/0.24。
遗传和共享环境因素对3至7岁内化和外化问题的稳定性最为重要。非共享环境因素主要具有年龄特异性。对于内化问题,共享环境可能从幼儿期到童年中期变得更加重要。