Nelson Lawrence M, Bakalov Vladimir K
Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Building 10, Room 10N262, Bethesda, MD 20892-1862, USA.
Endocrinol Metab Clin North Am. 2003 Sep;32(3):613-37. doi: 10.1016/s0889-8529(03)00043-4.
Approximately one half of young women who have 46,XX spontaneous premature ovarian failure have ovarian follicles remaining in the ovary. These follicles function intermittently and unpredictably, and pregnancies can occur in these women without intervention, even many years after the diagnosis. Clearly, the term "premature menopause" is an inaccurate term for this condition. At present, there are no proven therapies that will improve follicular function for these women. Inappropriate luteinization related to low follicle number seems to be a major mechanism of follicular dysfunction. Autoimmune oophoritis, although apparently an uncommon cause of follicular dysfunction in these women, nonetheless presents the opportunity to develop an effective therapy to restore fertility. Young women with 46,XX spontaneous premature ovarian failure benefit from the care of a sensitive clinician, one who is willing to spend a little more time informing them about the diagnosis and referring them to other sources of information. With appropriate medical management and emotional support provided by a sensitive clinician, most young women with 46,XX spontaneous premature ovarian failure will lead happy, healthy, and fulfilling lives.
约一半患有46,XX型特发性卵巢早衰的年轻女性卵巢中仍有卵泡。这些卵泡功能间歇性且不可预测，即便在诊断多年后，这些女性在未接受干预的情况下也可能怀孕。显然，“过早绝经”这一术语并不准确描述这种情况。目前，尚无经证实能改善这些女性卵泡功能的疗法。卵泡数量少导致的不适当黄素化似乎是卵泡功能障碍的主要机制。自身免疫性卵巢炎虽然显然是这些女性卵泡功能障碍的罕见原因，但仍为开发恢复生育能力的有效疗法提供了契机。患有46,XX型特发性卵巢早衰的年轻女性受益于敏感临床医生的照料，即愿意花更多时间告知她们诊断情况并将她们转介至其他信息来源的医生。在敏感临床医生提供的适当医疗管理和情感支持下，大多数患有46,XX型特发性卵巢早衰的年轻女性将过上幸福、健康且充实的生活。
