Bakalov Vladimir K, Anasti James N, Calis Karim A, Vanderhoof Vien H, Premkumar Ahalya, Chen Shu, Furmaniak Jadwiga, Smith B Rees, Merino Maria J, Nelson Lawrence M
Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, Maryland, USA.
Fertil Steril. 2005 Oct;84(4):958-65. doi: 10.1016/j.fertnstert.2005.04.060.
To assess the association between serum adrenal cortex autoantibodies and histologically confirmed autoimmune lymphocytic oophoritis.
Controlled, prospective.
Tertiary research center.
PATIENT(S): Two hundred sixty-six women with 46,XX spontaneous premature ovarian failure.
INTERVENTION(S): Ovarian biopsy in 10 women.
MAIN OUTCOME MEASURE(S): Serum adrenal cortex autoantibodies assessed by indirect immunofluorescence and autoimmune oophoritis assessed by immunohistochemical lymphocyte markers.
RESULT(S): We obtained a histologic diagnosis of autoimmune oophoritis in four women who tested positive for adrenal cortex autoantibodies and excluded this diagnosis in ovarian biopsies from six women who tested negative for adrenal cortex autoantibodies (4/4 vs. 0/6). Women with histologically confirmed autoimmune oophoritis had a greater total ovarian volume as assessed by transvaginal sonography (11.4 +/- 5.6 mL vs. 1.5 +/- 0.4 mL) (mean +/- SEM). They were also more likely to have subclinical adrenal insufficiency and clinical signs of androgen deficiency (3/4 vs. 0/6). Overall, 10/266 women tested positive for adrenal cortex autoantibodies (3.8%, 95% confidence interval: 1.8%-6.5%).
CONCLUSION(S): In women who present with 46,XX spontaneous premature ovarian failure as their primary concern there is a clear association between serum adrenal cortex autoantibodies and the presence of histologically confirmed autoimmune oophoritis.
评估血清肾上腺皮质自身抗体与组织学确诊的自身免疫性淋巴细胞性卵巢炎之间的关联。
对照、前瞻性研究。
三级研究中心。
266名46,XX型特发性卵巢早衰女性。
对10名女性进行卵巢活检。
通过间接免疫荧光法评估血清肾上腺皮质自身抗体，通过免疫组化淋巴细胞标志物评估自身免疫性卵巢炎。
我们在4名肾上腺皮质自身抗体检测呈阳性的女性中获得了自身免疫性卵巢炎的组织学诊断，并在6名肾上腺皮质自身抗体检测呈阴性的女性的卵巢活检中排除了该诊断（4/4 vs. 0/6）。经阴道超声检查评估，组织学确诊为自身免疫性卵巢炎的女性卵巢总体积更大（11.4±5.6 mL vs. 1.5±0.4 mL）（均值±标准误）。她们也更有可能存在亚临床肾上腺功能不全和雄激素缺乏的临床体征（3/4 vs. 0/6）。总体而言，266名女性中有10名肾上腺皮质自身抗体检测呈阳性（3.8%，95%置信区间：1.8%-6.5%）。
对于以46,XX型特发性卵巢早衰为主要问题的女性，血清肾上腺皮质自身抗体与组织学确诊的自身免疫性卵巢炎的存在之间存在明确关联。
