Rho Mun-Chual, Chung Mi Yeon, Song Hye Young, Kwon Oh Eok, Lee Seung Woong, Baek Jin Ah, Jeune Kyung Hee, Kim Koanhoi, Lee Hyun Sun, Kim Young Kook
Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea.
Arch Pharm Res. 2003 Sep;26(9):716-8. doi: 10.1007/BF02976679.
In the course of our search for Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors from natural sources, a new type of ACAT inhibitor was isolated from a methanol extract of Diospyros kaki. On the basis of spectral and structural evidence, the compound was identified as pheophorbide A-methyl ester. Pheophorbide A-methyl ester inhibited ACAT activity in a dose dependent manner with an IC50 value of 1.85 microg/mL.
在我们从天然来源寻找酰基辅酶A：胆固醇酰基转移酶（ACAT）抑制剂的过程中，从柿树的甲醇提取物中分离出一种新型的ACAT抑制剂。根据光谱和结构证据，该化合物被鉴定为脱镁叶绿酸A甲酯。脱镁叶绿酸A甲酯以剂量依赖的方式抑制ACAT活性，IC50值为1.85微克/毫升。
