Meance Séverine, Boutron-Ruault Marie-Christine, Myara Anne, Gerhardt Marie-France, Marteau Philippe, Lavergne Anne, Franchisseur Claire, Bouley Christine
Danone Vitapole, Palaiseau, France.
Dig Dis Sci. 2003 Sep;48(9):1751-7. doi: 10.1023/a:1025443012049.
In order to identify biomarkers of colorectal tumors, 20 subjects with colorectal adenomas were compared with 20 controls as regards fecal parameters (pH, short-chain fatty acids, bile acids, and sterols), blood parameters (bile acids, cholesterol, triglycerides, glycemia and insulinemia), and rectal cell proliferation. Variables were compared by unconditional logistic regression, controlling for gender. There were significant and positive associations between risk of adenoma and total fecal primary bile acids and serum cholesterol, with odds ratios for the third versus first tertile = 9.4 (P for trend = 0.03) and 8.6 (P for trend = 0.04), respectively. There was a trend towards an increased triglycerides level in adenoma subjects compared with controls (P = 0.08). These three parameters correlated with cell proliferation, although cell proliferation itself was not significantly associated with adenomas. In conclusion, these results suggest that fecal primary bile acids and serum cholesterol are markers of early events of colorectal carcinogenesis.
为了识别结直肠肿瘤的生物标志物，将20名患有结肠直肠腺瘤的受试者与20名对照者在粪便参数（pH值、短链脂肪酸、胆汁酸和固醇）、血液参数（胆汁酸、胆固醇、甘油三酯、血糖和胰岛素血症）以及直肠细胞增殖方面进行了比较。通过无条件逻辑回归对变量进行比较，并对性别进行了控制。腺瘤风险与粪便中总初级胆汁酸和血清胆固醇之间存在显著的正相关，第三分位数与第一分位数的比值比分别为9.4（趋势P值=0.03）和8.6（趋势P值=0.04）。与对照组相比，腺瘤受试者的甘油三酯水平有升高趋势（P=0.08）。这三个参数与细胞增殖相关，尽管细胞增殖本身与腺瘤并无显著关联。总之，这些结果表明粪便初级胆汁酸和血清胆固醇是结直肠癌发生早期事件的标志物。
