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Is it acceptable to approach colorectal cancer patients at diagnosis to discuss genetic testing? A pilot study.在结直肠癌患者确诊时就与他们讨论基因检测是否可行？一项试点研究。
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2
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Reflex testing for Lynch syndrome: if we build it, will they come? Lessons learned from the uptake of clinical genetics services by individuals with newly diagnosed colorectal cancer (CRC).林奇综合征的反射检测：如果我们开展这项检测，患者会前来吗？从新诊断为结直肠癌（CRC）的个体对临床遗传学服务的接受情况中吸取的经验教训。
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How do we approach the goal of identifying everybody with Lynch syndrome?我们如何实现识别每一位林奇综合征患者的目标？
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Psychological distress in newly diagnosed colorectal cancer patients following microsatellite instability testing for Lynch syndrome on the pathologist's initiative.在病理医生主动进行林奇综合征的微卫星不稳定性检测后，新诊断出的结直肠癌患者出现心理困扰。
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本文引用的文献

1
Genetic counseling and testing in families with hereditary nonpolyposis colorectal cancer.遗传性非息肉病性结直肠癌家族中的遗传咨询与检测
Arch Intern Med. 2003 Mar 10;163(5):573-82. doi: 10.1001/archinte.163.5.573.
2
Comprehensive genetic counseling for families at risk for HNPCC: impact on distress and perceptions.对遗传性非息肉病性结直肠癌（HNPCC）风险家庭的全面遗传咨询：对痛苦和认知的影响。
Genet Test. 2002 Winter;6(4):291-302. doi: 10.1089/10906570260471822.
3
Attitudes toward genetic testing in patients with colorectal cancer.结直肠癌患者对基因检测的态度。
Cancer Pract. 2000 Jul-Aug;8(4):178-86. doi: 10.1046/j.1523-5394.2000.84008.x.
4
Motivations and psychosocial impact of genetic testing for HNPCC.遗传性非息肉病性结直肠癌基因检测的动机及社会心理影响
Am J Med Genet. 2001 Sep 15;103(1):9-15.
5
Incidence of hereditary non-polyposis colorectal cancer in a population-based study of 1137 consecutive cases of colorectal cancer.在一项基于人群的1137例连续结直肠癌病例研究中遗传性非息肉病性结直肠癌的发病率
Br J Surg. 1997 Sep;84(9):1281-5.
6
Correlates of psychologic distress in colorectal cancer patients undergoing genetic testing for hereditary colon cancer.接受遗传性结肠癌基因检测的结直肠癌患者心理困扰的相关因素。
Health Psychol. 1997 Jan;16(1):73-86. doi: 10.1037//0278-6133.16.1.73.
7
Cancer risk associated with germline DNA mismatch repair gene mutations.与种系DNA错配修复基因突变相关的癌症风险
Hum Mol Genet. 1997 Jan;6(1):105-10. doi: 10.1093/hmg/6.1.105.

在结直肠癌患者确诊时就与他们讨论基因检测是否可行？一项试点研究。

Is it acceptable to approach colorectal cancer patients at diagnosis to discuss genetic testing? A pilot study.

作者信息

Porteous M, Dunckley M, Appleton S, Catt S, Dunlop M, Campbell H, Cull A

机构信息

Department of Clinical Genetics, Molecular Medicine Centre, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU, UK.

出版信息

Br J Cancer. 2003 Oct 20;89(8):1400-2. doi: 10.1038/sj.bjc.6601332.

DOI:10.1038/sj.bjc.6601332
PMID:14562005
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2394344/
Abstract

In this pilot study, the acceptability of approaching 111 newly diagnosed colorectal cancer patients with the offer of genetic testing for hereditary nonpolyposis colorectal cancer (HNPCC) was assessed. A total of 78% of participants found it highly acceptable to have the information about HNPCC brought to their attention at that time.

摘要

在这项试点研究中，评估了向111名新诊断出的结直肠癌患者提供遗传性非息肉病性结直肠癌（HNPCC）基因检测的可接受性。共有78%的参与者认为在那个时候让他们了解HNPCC的信息是非常可以接受的。