伊朗献血者血清丙氨酸氨基转移酶水平的健康范围。
Healthy ranges of serum alanine aminotransferase levels in Iranian blood donors.
作者信息
Mohamadnejad Mehdi, Pourshams Akram, Malekzadeh Reza, Mohamadkhani Ashraf, Rajabiani Afsaneh, Asgari Ali Ali, Alimohamadi Seyed Meysam, Razjooyan Hadi, Mamar-Abadi Mansooreh
机构信息
Digestive Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
World J Gastroenterol. 2003 Oct;9(10):2322-4. doi: 10.3748/wjg.v9.i10.2322.
AIM
The healthy ranges for serum alanine aminotransferase (ALT) levels are less well studied. The aim of this study was to define the upper limit of normal (ULN) for serum ALT levels, and to assess factors associated with serum ALT activity in apparently healthy blood donors.
METHODS
A total of 1,939 blood donors were included. ALT measurements were performed for all cases using the same laboratory method. Healthy ranges for ALT levels were computed from the population at the lowest risk for liver disease. Univariate and multivariate analyses were performed to evaluate associations between clinical factors and ALT levels.
RESULTS
Serum ALT activity was independently associated with body mass index (BMI) and male gender, but not associated with age. Association of ALT with BMI was more prominent in males than in females. Upper limit of normal for non-overweight women (BMI of less than 25) was 34 U/L, and for non-overweight men was 40 U/L.
CONCLUSION
Serum ALT is strongly associated with sex and BMI. The normal range of ALT should be defined for male and female separately.
目的
血清丙氨酸氨基转移酶（ALT）水平的健康范围研究较少。本研究的目的是确定血清ALT水平的正常上限（ULN），并评估明显健康的献血者中与血清ALT活性相关的因素。
方法
共纳入1939名献血者。所有病例均采用相同的实验室方法进行ALT检测。从肝病风险最低的人群中计算出ALT水平的健康范围。进行单因素和多因素分析以评估临床因素与ALT水平之间的关联。
结果
血清ALT活性与体重指数（BMI）和男性性别独立相关，但与年龄无关。ALT与BMI的关联在男性中比在女性中更显著。非超重女性（BMI小于25）的正常上限为34 U/L，非超重男性为40 U/L。
结论
血清ALT与性别和BMI密切相关。应分别为男性和女性定义ALT的正常范围。
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