Division of Occupational and Environmental Health, College of Public Health, Nantong University, Se Yuan Road, No. 8, Nantong 226019, China.
Int J Environ Res Public Health. 2018 Jan 4;15(1):71. doi: 10.3390/ijerph15010071.
At present, a large number of studies indicate that high dose ionizing radiation exposure is an important risk factor for liver damage. Whether protracted exposure to low external doses of ionizing radiation could induce liver injury is unclear. The aim of this study was to assess the risk of liver injury following protracted exposure to occupational radiation compared to a group of unexposed workers.
A three-year cohort study was initiated in Xinjiang, China in 2010 and included 508 industrial radiographers and 2156 unexposed workers. The incidence of liver injury was assessed clinically based on the evaluation of alanine aminotransferase (ALT) and aspartate transaminase (AST) levels. Logistic regression was used to examine whether radiation is a risk factor for liver injury.
Compared with the unexposed group, protracted radiation exposure was found to be a risk factor for liver injury. Sex, age at baseline and alcohol consumption were not associated with liver injury. However, hypertension was a risk factor for liver injury. The association between cumulative recorded radiation dose and liver injury was not found in this study.
These findings indicate that protracted exposure to radiation is a risk factor for liver injury.
目前，大量研究表明，大剂量电离辐射暴露是肝损伤的一个重要危险因素。然而，长期低剂量外照射是否会导致肝损伤尚不清楚。本研究旨在评估与未接触辐射的工人相比，长期职业辐射暴露对肝损伤的风险。
2010 年在中国新疆启动了一项为期 3 年的队列研究，纳入了 508 名工业放射技师和 2156 名未接触辐射的工人。根据丙氨酸氨基转移酶（ALT）和天冬氨酸氨基转移酶（AST）水平评估，临床评估肝损伤的发生率。采用 logistic 回归分析检查辐射是否是肝损伤的危险因素。
与未接触组相比，长期辐射暴露被认为是肝损伤的一个危险因素。性别、基线时的年龄和饮酒与肝损伤无关。然而，高血压是肝损伤的一个危险因素。本研究未发现累积记录辐射剂量与肝损伤之间的关联。
这些发现表明，长期辐射暴露是肝损伤的一个危险因素。
