Najmy Shaneez, Duseja Ajay, Pal Arnab, Sachdev Suchet, Sharma Rati R, Marwah Neelam, Chawla Yogesh
Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Department of Hepatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
J Clin Exp Hepatol. 2019 Mar-Apr;9(2):191-199. doi: 10.1016/j.jceh.2018.06.003. Epub 2018 Jun 21.
The normal range for Aspartate and Alanine Aminotransferases (AST and ALT) levels (<40 IU/L) were set in 1950s. Recent data from certain countries suggest lower levels of AST and ALT. Aim of the study was to redefine the normal values of aminotransferases in healthy Indian adults.
In a cross sectional prospective study, 1002 blood donors were evaluated to isolate a healthy cohort. Four and 9 subjects positive for HBsAg and anti-Hepatitis C Virus (HCV) respectively and three females were excluded. 986 male subjects were evaluated for levels of serum aminotransferases.
Of total 986 subjects (Group I), 543 (55.1%) had fatty liver on ultrasound [15 (1.5%) alcoholic fatty liver and 528 (53.5%) Nonalcoholic Fatty Liver Disease (NAFLD)]. Median AST and ALT in total group (Group I) were 27.69 (Interquartile Range (IQR) 22.33-37.04) and 34.19 IU/L (IQR 23.12-54.87) and in NAFLD (Group II) were 35.67 (IQR -27.49-47.43) and 50.36 (IQR 37.70-76.58) IU/L. Of remaining 443 subjects without fatty liver, 288 had one or more components of metabolic syndrome. Out of 155 patients with no fatty liver and no component of metabolic syndrome (Group III), 103 subjects had normal Body Mass Index (BMI) and normal cholesterol and Low Density Lipoprotein (LDL) (Group III). Median AST and ALT in Group III were 22.56 (IQR 20.23-26.91) and 21.36 (IQR 17.49-27.21) U/L respectively with a 95th percentile of 34.28 and 36.57 U/L for AST and ALT, respectively.
Levels of AST and ALT in healthy men are lower than the conventional values in India.
天冬氨酸氨基转移酶和丙氨酸氨基转移酶（AST和ALT）水平的正常范围（<40 IU/L）于20世纪50年代确定。来自某些国家的最新数据表明AST和ALT水平较低。本研究的目的是重新定义健康印度成年人氨基转移酶的正常值。
在一项横断面前瞻性研究中，对1002名献血者进行评估以分离出一个健康队列。分别排除4名HBsAg阳性和9名抗丙型肝炎病毒（HCV）阳性的受试者以及3名女性。对986名男性受试者的血清氨基转移酶水平进行评估。
在总共986名受试者（第一组）中，543名（55.1%）经超声检查患有脂肪肝[15名（1.5%）酒精性脂肪肝和528名（53.5%）非酒精性脂肪性肝病（NAFLD）]。整个组（第一组）的AST和ALT中位数分别为27.69（四分位间距（IQR）22.33 - 37.04）和34.19 IU/L（IQR 23.12 - 54.87），NAFLD组（第二组）的AST和ALT中位数分别为35.67（IQR - 27.49 - 47.43）和50.36（IQR 37.70 - 76.58）IU/L。在其余443名无脂肪肝的受试者中，288名有代谢综合征的一种或多种成分。在155名无脂肪肝且无代谢综合征成分的患者（第三组）中，103名受试者体重指数（BMI）正常且胆固醇和低密度脂蛋白（LDL）正常（第三组）。第三组的AST和ALT中位数分别为22.56（IQR 20.23 - 26.91）和21.36（IQR 17.49 - 27.21）U/L，AST和ALT的第95百分位数分别为34.28和36.57 U/L。
健康男性的AST和ALT水平低于印度的传统值。
