Maron B J, Ferrans V J
Am J Pathol. 1973 Oct;73(1):81-96.
Multiple intercalated discs were frequently observed in muscle cells from patients with cardiac hypertrophy of various causes. Evidence is presented that these structures are the intercellular junctions of lateral processes of muscle cells. The sizes and shapes of these processes showed marked variations, depending in part on the plane of sectioning. It is postulated that lateral processes develop in certain cells which have side-to-side intercellular junctions with adjacent cells, and that localized mechanical tensions induce their growth. These tensions are due to shearing forces exerted at side-to-side junctions when contraction occurs at different rates or magnitudes in adjacent cells. These forces lead to asymmetric and complementary growth of sarcomeres along the two sides of the lateral junctions, to reorientation of these junctions and to the eventual formation of lateral processes.
在各种原因导致的心脏肥大患者的肌肉细胞中经常观察到多个闰盘。有证据表明，这些结构是肌肉细胞侧向突起的细胞间连接。这些突起的大小和形状表现出明显的变化，部分取决于切片平面。据推测，侧向突起在某些与相邻细胞具有侧向细胞间连接的细胞中发育，并且局部机械张力诱导其生长。这些张力是由于相邻细胞以不同速率或幅度收缩时在侧向连接处施加的剪切力所致。这些力导致肌节沿侧向连接两侧不对称且互补生长，使这些连接重新定向并最终形成侧向突起。
