Lyketsos Constantine G, Lee Hochang B
Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287-5371, USA.
Dement Geriatr Cogn Disord. 2004;17(1-2):55-64. doi: 10.1159/000074277. Epub 2003 Oct 15.
Over 80% of patients with Alzheimer's disease (AD) develop 'noncognitive' neuropsychiatric symptoms at some point during the course of their illness. Depression is among the most frequent of such comorbidities. Affecting up to 50% of AD patients, depression is associated with severe negative consequences for patients and caregivers. Despite having a presentation in the context of AD that differs from typical 'geriatric' depression, it can be detected and quantified reliably, and can be differentiated from the other neuropsychiatric symptoms of AD. Several effective treatment modalities for depression in AD are available. In many cases, these reduce its adverse impact on patients and caregivers. This paper provides an overview of current knowledge regarding depression in AD for the clinician. It is followed by a practical discussion of the detection, evaluation, quantification, differential diagnosis and treatment of depression in AD.
超过80%的阿尔茨海默病（AD）患者在病程的某个阶段会出现“非认知性”神经精神症状。抑郁症是此类共病中最常见的症状之一。抑郁症影响高达50%的AD患者，对患者及其照料者会产生严重的负面后果。尽管AD患者所患抑郁症的表现与典型的“老年”抑郁症有所不同，但它能够被可靠地检测和量化，并且能够与AD的其他神经精神症状相鉴别。目前有几种针对AD患者抑郁症的有效治疗方法。在许多情况下，这些方法可减轻其对患者及其照料者的不利影响。本文为临床医生提供了关于AD患者抑郁症的当前知识概述。随后对AD患者抑郁症的检测、评估、量化、鉴别诊断及治疗进行了实际讨论。
