Martinez-Moczygemba Margarita, Huston David P
Biology of Inflammation Center, Departments of Medicine and Immunology, Baylor College of Medicine, Houston, TX, USA.
J Allergy Clin Immunol. 2003 Oct;112(4):653-65; quiz 666. doi: 10.1016/S0091.
IL-3, IL-5, and GM-CSF are related hematopoietic cytoines that are important for allergic inflammation. The receptors for human IL-5, IL-3, and GM-CSF are members of the hematopoietin receptor superfamily and are comprised of a cytokine-specific alpha chain and the common beta chain that is shared among these cytokines for signaling. Each of these cytokines contributes to the differentiation and function of leukocyte subpopulations and have clinical importance in protective immunity and in the pathophysiology of a spectrum of immunologic diseases that are as diverse as allergy and asthma, pulmonary alveolar proteinosis, neurodegenerative diseases, and malignancies. Delineating the biology of these cytokines is enabling the development of new strategies for diagnosing and treating these diseases and modulating immune responses.
白细胞介素-3（IL-3）、白细胞介素-5（IL-5）和粒细胞-巨噬细胞集落刺激因子（GM-CSF）是与造血相关的细胞因子，对过敏性炎症很重要。人IL-5、IL-3和GM-CSF的受体是造血受体超家族的成员，由细胞因子特异性α链和这些细胞因子共有的用于信号传导的β链组成。这些细胞因子中的每一种都有助于白细胞亚群的分化和功能，并且在保护性免疫以及一系列免疫疾病（如过敏和哮喘、肺泡蛋白沉积症、神经退行性疾病和恶性肿瘤）的病理生理学中具有临床重要性。阐明这些细胞因子的生物学特性有助于开发诊断和治疗这些疾病以及调节免疫反应的新策略。
