Division of Life Science, College of Natural Sciences, Gyeongsang National University, Jinju 52828, Republic of Korea.
Division of Applied Life Science (BK21 Four), Research Institute of Life Sciences, Gyeongsang National University, Jinju 52828, Republic of Korea.
Int J Mol Sci. 2023 May 29;24(11):9418. doi: 10.3390/ijms24119418.
Syntenin acts as an adaptor and scaffold protein through its two PSD-95, Dlg, and ZO-1 (PDZ) domains, participating in multiple signaling pathways and modulating cellular physiology. It has been identified as an oncogene, promoting cancer development, metastasis, and angiogenesis in various carcinomas. Syntenin-1 is also associated with the production and release of exosomes, small extracellular vesicles that play a significant role in intercellular communication by containing bioactive molecules such as proteins, lipids, and nucleic acids. The trafficking of exosomes involves a complex interplay of various regulatory proteins, including syntenin-1, which interacts with its binding partners, syndecan and activated leukocyte cell adhesion molecule (ALIX). Exosomal transfer of microRNAs, a key cargo, can regulate the expression of various cancer-related genes, including syntenin-1. Targeting the mechanism involving the regulation of exosomes by syntenin-1 and microRNAs may provide a novel treatment strategy for cancer. This review highlights the current understanding of syntenin-1's role in regulating exosome trafficking and its associated cellular signaling pathways.
衔接蛋白通过其两个 PDZ 结构域 PSD-95、Dlg 和 ZO-1（PDZ）充当衔接蛋白和支架蛋白，参与多种信号通路并调节细胞生理学。它已被确定为一种癌基因，促进各种癌中的癌症发展、转移和血管生成。衔接蛋白-1也与外泌体的产生和释放有关，外泌体是一种小的细胞外囊泡，通过包含生物活性分子（如蛋白质、脂质和核酸）在细胞间通讯中发挥重要作用。外泌体的运输涉及各种调节蛋白的复杂相互作用，包括与结合伴侣 syndecan 和活化白细胞细胞间黏附分子（ALIX）相互作用的衔接蛋白-1。微 RNA 等关键货物的外泌体转移可以调节各种与癌症相关的基因的表达，包括衔接蛋白-1。靶向涉及衔接蛋白-1和微 RNA 调节外泌体的机制可能为癌症提供一种新的治疗策略。本综述强调了目前对衔接蛋白-1在调节外泌体运输及其相关细胞信号通路中的作用的理解。
